Further validation of the association between MAPT haplotype-tagging polymorphisms and Alzheimer’s disease: neuropsychological tests, cerebrospinal fluid biomarkers, and APOE genotype

IntroductionGenetic studies have shown that variants in the microtubule-associated protein tau (MAPT) gene, which encodes tau protein, can increase the risk for Alzheimer’s disease (AD). Additionally, two haplotypes of the MAPT gene (H1 and H2) are associated with various neurodegenerative disorders...

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Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Mirjana Babić Leko, Ena Španić Popovački, Nanet Willumsen, Matea Nikolac Perković, Nikolina Pleić, Klara Zubčić, Lea Langer Horvat, Željka Vogrinc, Marina Boban, Fran Borovečki, Tatijana Zemunik, Rohan de Silva, Goran Šimić
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	Alzheimer’s disease APOE gene biomarkers cerebrospinal fluid dementia MAPT gene
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2024.1456670/full