Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible patterning can be achieved with diffusing molecules, especially when that patterning concerns differentiation of thin tissues. Wnt is a morphogen that orga...

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Bibliographic Details

Published in:	eLife
Main Authors:	Takayoshi Yamamoto, Yuta Kambayashi, Yuta Otsuka, Boni A Afouda, Claudiu Giuraniuc, Tatsuo Michiue, Stefan Hoppler
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2022-08-01
Subjects:	Wnt signal frizzled heart gene regulatory circuit morphogen Xenopus
Online Access:	https://elifesciences.org/articles/73818