Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2

Human tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the synthesis of serotonin. Its dysfunction has been implicated in various psychiatric disorders such as depression, autism, and bipolar disorder. TPH2 is typically decreased in stability and catalytic activity in patients; thus, s...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Kongfu Zhu, Chao Liu, Yuanzhu Gao, Jianping Lu, Daping Wang, Huawei Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	serotonin psychological disorders TPH2 virtual screening MD simulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.907437/full