Absence of BBSome function leads to astrocyte reactivity in the brain

Abstract In humans, dysfunctional primary cilia result in Bardet-Biedl syndrome (BBS), which presents with clinical features including intellectual disabilities, obesity, and retinal degeneration, and, in mouse models, the added feature of hydrocephalus. We observed increased Glial Fibrillary Acidic...

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Bibliographic Details

Published in:	Molecular Brain
Main Authors:	Minati Singh, Janelle E. Garrison, Kai Wang, Val C. Sheffield
Format:	Article
Language:	English
Published:	BMC 2019-05-01
Subjects:	BBS Reactive astrocytes Neuroinflammation And microglia
Online Access:	http://link.springer.com/article/10.1186/s13041-019-0466-z