Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus

Frontotemporal lobar degeneration (FTLD) is a group of clinically, pathologically and genetically heterogeneous neurodegenerative disorders that involve the frontal and temporal lobes. Behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and progressive non-fluent aphasia (PNF...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Gen Sobue, Shinsuke Ishigaki, Hirohisa Watanabe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-07-01
Subjects:	frontotemporal lobar degeneration loss of function tau proteins fused in sarcoma/translated in liposarcoma amyotrophic lateral sclerosis TDP-43 proteinopathies
Online Access:	https://www.frontiersin.org/article/10.3389/fnins.2018.00473/full