Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages

Hepatotoxicity or drug-induced liver injury (DILI) is a major safety issue in drug development as a primary reason for drug failure in clinical trials and the main cause for post-marketing regulatory measures like drug withdrawal. Idiosyncratic DILI (iDILI) is a patient-specific, multifactorial, and...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Estela Villanueva-Badenas, M. Teresa Donato, Laia Tolosa
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	hepatocyte Kupffer cell macrophages idiosyncratic hepatotoxicity drug oxidative stress
Online Access:	https://www.mdpi.com/2076-3921/12/7/1315