Glycoengineering of plant-produced Pembrolizumab enhances FcRn binding and extends serum half-life in mice

Plant systems offer scalable and cost-effective platforms for antibody production, but plant-specific glycans may affect pharmacokinetics and immunogenicity. To evaluate the impact of Fc glycosylation, four Pembrolizumab glycovariants were generated in Nicotiana benthamiana: wild-type glycosylation...

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發表在:	Biotechnology Reports
Main Authors:	Christine Joy I. Bulaon, Janejira Jaratsittisin, Kaewta Rattanapisit, Pipob Suwanchaikasem, Shiying Guo, Khwanchit Boonha, Pannamthip Pitaksajjakul, Nipaporn Simsom, Vudhiporn Limprasutr, Waranyoo Phoolcharoen
格式:	Article
語言:	英语
出版:	Elsevier 2025-12-01
主題:	Pembrolizumab Nicotiana benthamiana Glycoengineering Fc glycosylation FcRn binding Pharmacokinetics
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2215017X25000542