Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization

Abstract Background Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitochondrial fission is a novel target for alleviating inflammatory disease...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, Min-ming Zheng, Qing-wei Chen
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Subjects:	Atherosclerosis Mdivi-1 DRP1 Mitochondrial fission M1 polarization NLRP3 inflammasome
Online Access:	https://doi.org/10.1186/s12967-023-04270-9