Loss of mitochondrial Ca2+ response and CaMKII/ERK activation by LRRK2R1441G mutation correlate with impaired depolarization-induced mitophagy

Abstract Background Stress-induced activation of ERK/Drp1 serves as a checkpoint in the segregation of damaged mitochondria for autophagic clearance (mitophagy). Elevated cytosolic calcium (Ca2+) activates ERK, which is pivotal to mitophagy initiation. This process is altered in Parkinson’s disease...

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書誌詳細

出版年:	Cell Communication and Signaling
主要な著者:	Eunice Eun-Seo Chang, Huifang Liu, Zoe Yuen-Kiu Choi, Yasine Malki, Steffi Xi-Yue Zhang, Shirley Yin-Yu Pang, Michelle Hiu-Wai Kung, David B. Ramsden, Shu-Leong Ho, Philip Wing-Lok Ho
フォーマット:	論文
言語:	英語
出版事項:	BMC 2024-10-01
主題:	Parkinson disease LRRK2 mutation Mitophagy Calcium-dependent pathways Mitochondrial dysfunction Cellular stress response
オンライン･アクセス:	https://doi.org/10.1186/s12964-024-01844-y