Mast Cell Chymase/Mcpt4 Suppresses the Host Immune Response to Plasmodium yoelii, Limits Malaria-Associated Disruption of Intestinal Barrier Integrity and Reduces Parasite Transmission to Anopheles stephensi

An increase in mast cells (MCs) and MCs mediators has been observed in malaria-associated bacteremia, however, the role of these granulocytes in malarial immunity is poorly understood. Herein, we studied the role of mouse MC protease (Mcpt) 4, an ortholog of human MC chymase, in malaria-induced bact...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Nora Céspedes, Erinn L. Donnelly, Casey Lowder, Gretchen Hansten, Delaney Wagers, Anna M. Briggs, Joseph Schauer, Lori Haapanen, Magnus Åbrink, Judy Van de Water, Shirley Luckhart
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	malaria bacteremia mast cells Mcpt4 chymase Plasmodium yoelii
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.801120/full