Histone deacetylase inhibition sensitizes p53-deficient B-cell precursor acute lymphoblastic leukemia to chemotherapy

In pediatric acute lymphoblastic leukemia (ALL), mutations/deletions affecting the TP53 gene are rare at diagnosis. However, at relapse about 12% of patients show TP53 aberrations, which are predictive of a very poor outcome. Since p53-mediated apoptosis is an endpoint for many cytotoxic drugs, los...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Willem P.J. Cox, Nils Evander, Dorette S. van Ingen Schenau, Gawin R. Stoll, Nadia Anderson, Lieke de Groot, Kari J.T. Grünewald, Rico Hagelaar, Miriam Butler, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2023-12-01
Online Access:	https://haematologica.org/article/view/11383