Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK/mTOR pathway

Epilepsy is one of the most common neurological disorders. Neuroinflammation involving the activation of microglia and astrocytes constitutes an important and common mechanism in epileptogenesis. Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable, non-selective cation channel t...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Chen Chen, Tao Zhu, Lifen Gong, Zhe Hu, Hao Wei, Jianchen Fan, Donghui Lin, Xiaojun Wang, Junyu Xu, Xinyan Dong, Yifan Wang, Ningxiao Xia, Linghui Zeng, Peifang Jiang, Yicheng Xie
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Subjects:	AMPK/mTOR pathway Astrocytes Autophagy Epileptogenesis Microglia Neuroinflammation
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996123002887