Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway

The neurotransmitter glutamate mediates excitatory synaptic transmission in the brain and spinal cord. In pathological conditions massive glutamate release reaches near millimolar concentrations in the extracellular space and contributes to neuron degeneration and death. In the present study, we dem...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Venkata Ramesh Dasari, Krishna Kumar Veeravalli, Kay L. Saving, Meena Gujrati, Dan Fassett, Jeffrey D. Klopfenstein, Dzung H. Dinh, Jasti S. Rao
Format:	Article
Language:	English
Published:	Elsevier 2008-12-01
Subjects:	Cord blood stem cells Cortical neurons Glutamate excitotoxicity NMDA receptors Neuroprotection Microarrays
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996108002118