Assessing blood-brain barrier dysfunction and its association with Alzheimer’s pathology, cognitive impairment and neuroinflammation

Abstract Background Blood-brain barrier (BBB) alterations may contribute to AD pathology through various mechanisms, including impaired amyloid-β (Aβ) clearance and neuroinflammation. Soluble platelet-derived growth factor receptor beta (sPDGFRβ) has emerged as a potential biomarker for BBB integrit...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Lukas Preis, Kersten Villringer, Frederic Brosseron, Emrah Düzel, Frank Jessen, Gabor C. Petzold, Alfredo Ramirez, Annika Spottke, Jochen B. Fiebach, Oliver Peters
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Alzheimer’s disease Mild cognitive impairment Blood-brain barrier Pericyte sPDGFRβ DCE-MRI
Online Access:	https://doi.org/10.1186/s13195-024-01529-1