High altitude polycythemia and its maladaptive mechanisms: an updated review

High altitude polycythemia is a maladaptation of highlanders exposed to hypoxic environment, leading to high blood viscosity and severe cardiorespiratory dysfunction. Prolonged hypoxia causes respiratory depression and severe hypoxemia, and further mediates changes in genetic and molecular mechanism...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Shijie Tang, Wenwen Zhou, Ling Chen, Hui Yan, Lei Chen, Fengming Luo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	excessive erythrocytosis high altitude polycythemia hypoxemia maladaptive mechanisms review
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2024.1448654/full