Structural basis of topoisomerase targeting by delafloxacin

Abstract Delafloxacin is a potent anionic fluoroquinolone approved for the treatment of respiratory infections that acts by trapping the DNA cleavage complexes of bacterial topoisomerase IV and gyrase. Its N-1-pyridinyl-, C-7-azetidinyl- and C-8-chlorine substituents confer enhanced antibiotic activ...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Shabir Najmudin, Xiao-Su Pan, Beijia Wang, Lata Govada, Naomi E. Chayen, Noelia Rubio, Milo S. P. Shaffer, Henry S. Rzepa, L. Mark Fisher, Mark R. Sanderson
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s41467-025-60688-3