Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

The development of clinically relevant anti-microRNA antisense oligonucleotides (anti-miRNA ASOs) remains a major challenge. One promising configuration of anti-miRNA ASOs called “tiny LNA (tiny Locked Nucleic Acid)” is an unusually small (~8-mer), highly chemically modified anti-miRNA ASO with high...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Tsuyoshi Yamamoto, Yahiro Mukai, Fumito Wada, Chisato Terada, Yukina Kayaba, Kaho Oh, Asako Yamayoshi, Satoshi Obika, Mariko Harada–Shiba
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Subjects:	tiny LNA miR-122 GalNAc Ligand-targeted drug delivery system antisense oligonucleotide
Online Access:	https://www.mdpi.com/1999-4923/13/6/817