Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome

Abstract Background Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying statistical assumptions, missing biological information, and high sample size requirement might make it prone to misuse....

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Systematic Reviews
المؤلفون الرئيسيون: Sandeep Grover, Fabiola Del Greco M., Inke R. König
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2018-09-01
الموضوعات:
Mendelian randomization
Instrumental variable
Observational epidemiology
Genome-wide association study
Summary data
Pleiotropy
الوصول للمادة أونلاين:http://link.springer.com/article/10.1186/s13643-018-0809-3

الانترنت

http://link.springer.com/article/10.1186/s13643-018-0809-3

مواد مشابهة