Formulation optimization of lyophilized aptamer-gold nanoparticles: Maintained colloidal stability and cellular uptake

Anti-nucleolin (NCL) aptamer AS1411 is the first anticancer aptamer tested in clinical trials. Gold nanoparticles (AuNP) have been widely exploited for various biomedical applications due to their unique functional properties. In this study, we evaluated the colloidal stability and targeting capacit...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Dalya Saidi, Marya Obeidat, Shrouq Alsotari, Abed-Alqader Ibrahim, Rula Al-Buqain, Suha Wehaibi, Dana A. Alqudah, Hamdi Nsairat, Walhan Alshaer, Alaaldin M. Alkilany
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Subjects:	Aptamer Gold nanoparticles Aggregation Cryoprotectants Lyophilization
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024067744