Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice

Abstract Target identification is a crucial step in elucidating the mechanisms by which functional food components exert their functions. Here, we identified the G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) as a target of the triterpenoid mogrol, a class of aglycone mogroside...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Chisato Tanaka, Naoki Harada, Yoshiaki Teraoka, Hiroki Urushizaki, Yoh Shinmori, Teruaki Onishi, Yusuke Yotsumoto, Yuta Ito, Tomoya Kitakaze, Takashi Inui, Yuji Murata, Hiroshi Inui, Ryoichi Yamaji
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Online Access:	https://doi.org/10.1038/s41598-024-53380-x