Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes

Abstract Background Chronic inflammation plays a vital role in the development of gestational diabetes mellitus (GDM). Studies in mouse models show that neutrophil serine proteases (NSPs), neutrophil elastase (NE) and proteinase-3 (PR3) are important drivers of chronic inflammation with consequent m...

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Bibliographic Details

Published in:	Reproductive Biology and Endocrinology
Main Authors:	Lihong Wang, Zhoujunhao Zhou, Xinming Xu, Yue Li, Rui Zhang, Zhiyan Yu, Xinmei Huang, Shufei Zang, Tiange Sun
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Subjects:	Gestational diabetes mellitus Neutrophil elastase Proteinase 3 Macrosomia Inflammation
Online Access:	https://doi.org/10.1186/s12958-023-01170-x