Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in T cells, effector Treg cell frequencies were elevated in mice and in in vitro-generated human Treg c...

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الحاوية / القاعدة:	eLife
المؤلفون الرئيسيون:	Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	eLife Sciences Publications Ltd 2024-10-01
الموضوعات:	T lymphocyte subsets regulatory T cells autoimmunity
الوصول للمادة أونلاين:	https://elifesciences.org/articles/78738