Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells

Abstract RNA medicine is an emerging groundbreaking technology for the prevention and treatment of disease. However, tools to deliver messenger RNA (mRNA) and other polyanions (circRNA, saRNA, pDNA, CRISPR-Cas, reprogramming factors) are required to advance current RNA therapies and address next gen...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Zhijian Li, Aloysius Ee, Laura Amaya, Jennifer L. Hamad, Pavan K. Yadav, Sean K. Wang, Howard Y. Chang, Paul A. Wender
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Online Access:	https://doi.org/10.1038/s41467-025-62200-3