Dimethyl Fumarate Protects Retinal Pigment Epithelium from Blue Light-Induced Oxidative Damage via the Nrf2 Pathway

The purpose of this study is to investigate the protective effect of dimethyl fumarate (DMF), the methyl-ester of fumaric acid, against blue-light (BL) exposure in retinal pigment epithelial (RPE) cells. ARPE-19 cells, a human RPE cell line, were cultured with DMF followed by exposure to BL. Reactiv...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Hideyuki Shimizu, Kei Takayama, Kazuhisa Yamada, Ayana Suzumura, Tomohito Sato, Yoshiaki Nishio, Masataka Ito, Hiroaki Ushida, Koji M Nishiguchi, Masaru Takeuchi, Hiroki Kaneko
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Subjects:	dimethyl fumarate blue-light nuclear factor (erythroid-derived)-like 2 retinal pigment epithelium oxidative stress NRF2 pathway
Online Access:	https://www.mdpi.com/2076-3921/12/1/45