Aerosolized nicotine-free e-liquid base constituents exacerbates mitochondrial dysfunction and endothelial glycocalyx shedding via the AKT/GSK3β-mPTP pathway in lung injury models

Abstract Smoking has been recognized as a risk factor of cancer, heart disease, stroke, diabetes, and lung diseases such as chronic obstructive pulmonary disease, and nicotine appears to be the responsible component of tobacco smoke that affects lung development. While nicotine-free electronic cigar...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Ziyu Dai, Bin Xie, Chen Jiang, Yun Peng, Jianing Lin, Qiong Chen, Jingyi Sun
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Nicotine-free e-cigarette Cytotoxicity Mitochondrial dysfunction Endothelial glycocalyx AKT/GSK3β pathway mPTP opening
Online Access:	https://doi.org/10.1186/s12931-025-03155-3