Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.

Osteonecrosis is a common dose-limiting toxicity of glucocorticoids. Data from clinical trials suggest that other medications can increase the risk of glucocorticoid-induced osteonecrosis. Here we utilized a mouse model to study the effect of asparaginase treatment on dexamethasone-induced osteonecr...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Chengcheng Liu, Laura J Janke, Jitesh D Kawedia, Laura B Ramsey, Xiangjun Cai, Leonard A Mattano, Kelli L Boyd, Amy J Funk, Mary V Relling
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151433&type=printable