Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats

Abstract The oral administration of insulin offers significant clinical benefits due to its simplicity. This study evaluated piperine’s efficacy in improving insulin’s intestinal absorption in Wistar rats. Confocal microscopy demonstrated that prolonged retention of insulin-loaded chitosan-coated so...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Indu Raghunath, Marina Koland, Suprit D. Saoji, Sarad Pawar Naik Bukke, N. Shridhar Deshpande, Varsha Augustin, Nilesh Rarokar, Chandrashekar Thalluri
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	Streptozotocin Wistar rats Insulin Solid lipid nanoparticles In vivo Diabetes
Online Access:	https://doi.org/10.1038/s41598-025-05137-3