Astrocytic 5-HT1A receptor mediates age-dependent hippocampal LTD and fear memory extinction in male mice

Abstract NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. Although the underlying mechanisms remain unclear, this form of LTD cannot be induced by low-frequency stimulation (LFS) i...

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Bibliographic Details

Published in:	Experimental and Molecular Medicine
Main Authors:	Qian-Yun Wu, Lian-Hong Lin, Kun Lu, Si-Fu Deng, Wei-Min Li, Yuan Xu, Bin Zhang, Ji-Hong Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-08-01
Online Access:	https://doi.org/10.1038/s12276-024-01285-0