Aging-dependent mitochondrial bioenergetic impairment in the skeletal muscle of NNT-deficient mice

Overall health relies on features of skeletal muscle that generally decline with age, partly due to mechanisms associated with mitochondrial redox imbalance and bioenergetic dysfunction. Previously, aged mice genetically devoid of the mitochondrial NAD(P)+ transhydrogenase (NNT, encoded by the nicot...

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Bibliographic Details

Published in:	Experimental Gerontology
Main Authors:	Claudia D.C. Navarro, Annelise Francisco, Ericka F.D. Costa, Ana P. Dalla Costa, Marina R. Sartori, Paulo F.V. Bizerra, Andréia R. Salgado, Tiago R. Figueira, Anibal E. Vercesi, Roger F. Castilho
Format:	Article
Language:	English
Published:	Elsevier 2024-08-01
Subjects:	Age-related muscle dysfunction Locomotor impairment Mitochondrial bioenergetics Nicotinamide nucleotide transhydrogenase NNT deficiency Oxidative stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S0531556524001074