Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells

The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-<i>N</i>-(4-((4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1<i>H...

Full description

Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Beate Sandra Hoffelner, Stanislav Andreev, Nicole Plank, Pierre Koch
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	kinase inhibitor pyridinyl imidazole covalent inhibitor photoactivation caging group JNK3
Online Access:	https://www.mdpi.com/1424-8247/16/2/264