Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.

Most monoclonal antibodies (mAbs) to the influenza A virus hemagglutinin (HA) head domain exhibit very limited breadth of inhibitory activity due to antigenic drift in field strains. However, mAb 1F1, isolated from a 1918 influenza pandemic survivor, inhibits select human H1 viruses (1918, 1943, 194...

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發表在:	PLoS Pathogens
Main Authors:	Tshidi Tsibane, Damian C Ekiert, Jens C Krause, Osvaldo Martinez, James E Crowe, Ian A Wilson, Christopher F Basler
格式:	Article
語言:	英语
出版:	Public Library of Science (PLoS) 2012-01-01
在線閱讀:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003067&type=printable