MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype

Abstract Background MLN4924 is a novel small molecule inhibitor of neddylation. During clinical trials, it has demonstrated promising therapeutic efficacy in hematological malignancies, lung cancer, and colon cancer. MLN4924 possesses anti-inflammatory properties and promotes cardiomyocyte autophagy...

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Bibliographic Details

Published in:	Lipids in Health and Disease
Main Authors:	Lei Xing, Yu Bu, Jingqi Shi, Jing Liu, Fan Hu, Minghua Zhang, Jiao Fan
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Atherosclerosis Autophagy MLN4924 Foam cells Macrophage
Online Access:	https://doi.org/10.1186/s12944-025-02683-7