Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein

AMG 256 is a bi-specific, heteroimmunoglobulin molecule with an anti-PD-1 antibody domain and a single IL-21 mutein domain on the C-terminus. Nonclinical studies in cynomolgus monkeys revealed that AMG 256 administration led to the development of immunogenicity-mediated responses and indicated that...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Mark A. Kroenke, Marta Starcevic Manning, Christina L. Zuch de Zafra, Xinwen Zhang, Kevin D. Cook, Michael Archer, Martijn P. Lolkema, Jin Wang, Sarah Hoofring, Gurleen Saini, Famke Aeffner, Elizabeth Ahern, Elena Garralda Cabanas, Ramaswamy Govindan, Mun Hui, Shalini Gupta, Daniel T. Mytych
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	PD-1 IL-21 immunogenicity anti-drug antibodies mutein IgE
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1345473/full