Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity

Abstract Background Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mitochondrial targeting activities. Herein, we investigated the capabilit...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande, Nicola Amodio
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	Flavanones Hesperitin Naringenin Mitochondrial dynamics Multiple myeloma
Online Access:	https://doi.org/10.1186/s12967-024-05013-0