Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity

Abstract Background Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mitochondrial targeting activities. Herein, we investigated the capabilit...

Full description

Bibliographic Details
Published in:	Journal of Translational Medicine
Main Authors:	Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande, Nicola Amodio
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	Flavanones Hesperitin Naringenin Mitochondrial dynamics Multiple myeloma
Online Access:	https://doi.org/10.1186/s12967-024-05013-0

Similar Items

Crystal structures of three newly synthesized flavanone hydrazones
by: Hemant P. Yennawar, et al.
Published: (2023-03-01)

Flavanones as Modulators of Gut Microbiota and Cognitive Function
by: Natalia Cichon, et al.
Published: (2025-05-01)

Naringenin, a citrus flavanone, enhances browning and brown adipogenesis: Role of peroxisome proliferator-activated receptor gamma
by: Jiyoung Bae, et al.
Published: (2022-11-01)

Effect of Structural Differences in Naringenin, Prenylated Naringenin, and Their Derivatives on the Anti-Influenza Virus Activity and Cellular Uptake of Their Flavanones
by: Ryosuke Morimoto, et al.
Published: (2022-11-01)

Polyphenols from Citrus Tacle<sup>®</sup> Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy
by: Fedora Grande, et al.
Published: (2021-09-01)

Geranyl flavanone from Feronia limonia (L.) Swingle
by: Urainab Sumia, et al.
Published: (2022-12-01)

Methoxy-Substituted γ-Oxa-ε-Lactones Derived from Flavanones—Comparison of Their Anti-Tumor Activity In Vitro
by: Aleksandra Pawlak, et al.
Published: (2021-10-01)

Isolation and Structure Elucidation of a Flavanone, a Flavanone Glycoside and Vomifoliol from Echiochilon Fruticosum Growing in Tunisia
by: Z. Mighri, et al.
Published: (2004-06-01)

Isolation and Molecular Characterization of the Naringinase Producing Micro-organisms for the Bio-transformation of Flavonoid
by: Ananda Sindhe, et al.
Published: (2023-03-01)

In Vitro Anti-Inflammatory Activity of Methyl Derivatives of Flavanone
by: Małgorzata Kłósek, et al.
Published: (2023-11-01)

An efficient and facile synthesis of flavanones catalyzed by N-methylimidazole
by: Wang Peng, et al.
Published: (2013-01-01)

Fucoidan/Polyvinylpyrrolidone/Hesperitin nanoparticle complex for corneal injury treatment: Synthesis, characterization, and therapeutic efficacy
by: Yalu Liu, et al.
Published: (2025-06-01)

Diuretic and Natriuretic Effects of Hesperidin, a Flavanone Glycoside, in Female and Male Hypertensive Rats
by: Priscila de Souza, et al.
Published: (2022-12-01)

Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples
by: Samya S. Alenezi, et al.
Published: (2020-12-01)

Flavanone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics for Mitochondria-Imaging and Zebrafish-Imaging
by: Na Li, et al.
Published: (2020-07-01)

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer
by: Maria Beatriz Madureira, et al.
Published: (2023-02-01)

In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors
by: Neelam Malik, et al.
Published: (2019-04-01)

A Structure–Activity Relationship Study on the Antioxidant Properties of Dithiocarbamic Flavanones
by: Mihail Lucian Birsa, et al.
Published: (2024-08-01)

Bibliometric Study of Microwave-Assisted Synthesis of Flavanone Derivatives
by: Hadi Poerwono, et al.
Published: (2023-11-01)

Five-Decade Update on Chemopreventive and Other Pharmacological Potential of Kurarinone: a Natural Flavanone
by: Shashank Kumar, et al.
Published: (2021-09-01)

Prenylation of Flavanones by an Aromatic Prenyltransferase from <i>Fusarium globosum</i>
by: Dingtao Tang, et al.
Published: (2025-03-01)

Antinociceptive and anti-inflammatory effects of the citrus flavanone naringenin
by: Ting-Wen Chung, et al.
Published: (2019-01-01)

Chalcones and Flavanones Bearing Hydroxyl and/or Methoxyl Groups: Synthesis and Biological Assessments
by: Gonçalo P. Rosa, et al.
Published: (2019-07-01)

Iodine-Substituted Dithiocarbamic Flavanones—A Structure–Activity Relationship Study of Their Antioxidant Properties
by: Mihail Lucian Birsa, et al.
Published: (2025-05-01)

New Insights into the Metabolism of the Flavanones Eriocitrin and Hesperidin: A Comparative Human Pharmacokinetic Study
by: María Ángeles Ávila-Gálvez, et al.
Published: (2021-03-01)

Potential inhibition of CXCL12/SDF-1 by small molecule Hesperetin in management of tobacco associated oral cancer
by: G. Radha, et al.
Published: (2024-03-01)

The Effect of Methyl-Derivatives of Flavanone on MCP-1, MIP-1β, RANTES, and Eotaxin Release by Activated RAW264.7 Macrophages
by: Małgorzata Kłósek, et al.
Published: (2024-05-01)

A New Prenylated Flavanone from Derris trifoliata Lour.
by: Hao Yin, et al.
Published: (2012-01-01)

Biological Properties and Absolute Configuration of Flavanones From Calceolariathyrsiflora Graham
by: Ernesto Valdés, et al.
Published: (2020-07-01)

In Silico Investigation of Flavanone Compounds\' Inhibitory Effects on Alpha-Amylase Enzyme and Predicting their Inhibitory Role in Diabetes Progression
by: Morteza Sadeghi, et al.
Published: (2020-11-01)

Potential of natural flavonols and flavanones in the treatment of ulcerative colitis
by: Cailan Li, et al.
Published: (2023-03-01)

Hesperitin-Copper(II) Complex Regulates the NLRP3 Pathway and Attenuates Hyperuricemia and Renal Inflammation
by: Xi Peng, et al.
Published: (2024-02-01)

The Callus of <i>Phaseolus coccineus</i> and <i>Glycine max</i> Biotransform Flavanones into the Corresponding Flavones
by: Monika Dymarska, et al.
Published: (2020-12-01)

Position Impact of Hydroxy Groups on Spectral, Acid–Base Profiles and DNA Interactions of Several Monohydroxy Flavanones
by: Elżbieta Łodyga-Chruścińska, et al.
Published: (2019-08-01)

In Vivo Anti-Inflammatory Evaluation and In Silico Physicochemical Characterization of Flavanones from <i>E. platycarpa</i> Leaves
by: Berenice Andrade-Carrera, et al.
Published: (2025-09-01)

Functional Characterization of Flavanone 3-Hydroxylase (F3H) and Its Role in Anthocyanin and Flavonoid Biosynthesis in Mulberry
by: Mingjie Dai, et al.
Published: (2022-05-01)

Effects of Flavanone Derivatives on Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells
by: Yasuhito Nobushi, et al.
Published: (2024-11-01)

In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones
by: Seungeun Lee, et al.
Published: (2018-06-01)

Association between intake of flavanones and the overweight/obesity and central obesity in children and adolescents: a cross-sectional study from the NHANES database
by: Yangyang Liu, et al.
Published: (2024-07-01)

Synthesis and Investigation of Flavanone Derivatives as Potential New Anti-Inflammatory Agents
by: Cynthia Sinyeue, et al.
Published: (2022-03-01)