The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis

Abstract The therapeutic efficacy of adoptive T cell therapy is largely restricted by reduced viability and dysfunction of CD8+ T cells. Continuous antigen stimulation disrupts the expansion, effector function, and metabolic fitness of CD8+ T cells, leading to their differentiation into an exhausted...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Xin Zhang, Jiajia Wang, Kun Tang, Yu Yang, Xiaowei Liu, Shengtao Yuan, Feng Guo, Lianjun Zhang, Kaili Ma
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-05-01
Online Access:	https://doi.org/10.1038/s41419-024-06721-7