Insulin reduces endoplasmic reticulum stress‐induced apoptosis by decreasing mitochondrial hyperpolarization and caspase‐12 in INS‐1 pancreatic β‐cells

Abstract Pancreatic β‐cell mass is a critical determinant of insulin secretion. Severe endoplasmic reticulum (ER) stress causes β‐cell apoptosis; however, the mechanisms of progression and suppression are not yet fully understood. Here, we report that the autocrine/paracrine function of insulin redu...

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Bibliographic Details

Published in:	Physiological Reports
Main Authors:	Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaji
Format:	Article
Language:	English
Published:	Wiley 2024-06-01
Subjects:	autocrine and paracrine actions of insulin caspase‐12 cytochrome c endoplasmic reticulum (ER) stress mitochondrial hyperactivation pancreatic β‐cells
Online Access:	https://doi.org/10.14814/phy2.16106