Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

Tau is a microtubule-associated protein which regulates the assembly and stability of microtubules in the axons of neurons. Tau is also a major component of neurofibrillary tangles (NFTs), a pathological hallmark in Alzheimer's disease (AD). A characteristic of AD tau is hyperphosphorylation wi...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Taeko Kimura, Govinda Sharma, Koichi Ishiguro, Shin-ichi Hisanaga
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-02-01
Subjects:	phos-tag tau phosphorylation Alzheimer' disease tauopathy Cdk5
Online Access:	http://journal.frontiersin.org/article/10.3389/fnins.2018.00044/full