Bioanalysis of bedaquiline in human plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study

Introduction: A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for estimation of bedaquiline (BDQ) in human plasma using the deuterated analogue of the analyte, bedaquiline-d6 (BDQ-d6) as the internal standard. Methods: The plasma sample of 50 µL was extract...

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Bibliographic Details

Published in:	Journal of Mass Spectrometry and Advances in the Clinical Lab
Main Authors:	Viritha Bezawada, Padma Mogili, Srinivasa Rao Polagani, Sireesha Dodda
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Bedaquiline LC-MS/MS Bioanalysis Liquid–liquid extraction Pharmacokinetic study Incurred sample reanalysis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667145X24000014