Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

Long-term administration of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) mimics the effects of endurance exercise by activating AMP kinase and by increasing skeletal muscle expression of GLUT4 glucose transporter. AICAR is an intermediate in the purine de novo synthesis, and its tissue conc...

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Bibliographic Details

Published in:	Journal of Nutrition and Metabolism
Main Authors:	Giuseppina T. Russo, Letteria Minutoli, Alessandra Bitto, Domenica Altavilla, Eugenio Alessi, Annalisa Giandalia, Elisabetta L. Romeo, Maria Francesca Stagno, Francesco Squadrito, Domenico Cucinotta, Jacob Selhub
Format:	Article
Language:	English
Published:	Wiley 2012-01-01
Online Access:	http://dx.doi.org/10.1155/2012/132056