Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease

Abstract Background Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpinning this dysregulation remain elusive. We hypothesised that lower DNase activity may be a...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Geoffrey Garcia, Sylvie Labrouche-Colomer, Alexandre Duvignaud, Etienne Clequin, Charles Dussiau, David-Alexandre Trégouët, Denis Malvy, Renaud Prevel, Atika Zouine, Isabelle Pellegrin, Julien Goret, Maria Mamani-Matsuda, Antoine Dewitte, Chloe James
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Online Access:	https://doi.org/10.1186/s12967-024-05044-7