The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity

Excessive long-term manganese intake can inflict irreversible damage to the nervous system, with a predominant effect on the substantia nigra-striatum pathway. Through a mouse model simulating manganese exposure, we delved into its implications on the central nervous motor system, uncovering autopha...

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Bibliographic Details

Published in:	Current Research in Toxicology
Main Authors:	Jiaqiao Lu, Peng Su, Fang Zhao, Kailun Yu, Xunbo Yang, Hui Lv, Diya Wang, Jianbin Zhang
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Manganese neurotoxicity Autophagy Lysosome TFEB
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666027X2400046X