Synthesis, molecular modelling and biological evaluation of new 4-aminothiophene and thienopyrimidine compounds

A series of 4-amino-5-substituted-thiophene derivatives 3, 5 and 7, along with their corresponding thieno[3,2-d]pyrimidine compounds 4, 6 and 8, were synthesized and characterized. DFT calculations were utilized to determine frontier orbitals energies. The data showed that the compounds have low HOM...

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Bibliographic Details

Published in:	Journal of Taibah University for Science
Main Authors:	Aisha Hossan, Mansoor Alsahag, Ali Alisaac, Majid A. Bamaga, Adel I. Alalawy, Nashwa M. El-Metwaly
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	4-Aminothiophene thienopyrimidine Mulliken’s charges antimicrobial HCT-116 molecular docking
Online Access:	https://www.tandfonline.com/doi/10.1080/16583655.2023.2164993