Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations

<i>N</i>1-(α,β-Alkene)-substituted phenylpyrazolopyrimidine derivatives with acetyl and functionalized phenyl groups at α- and β-positions, respectively, were synthesized by the reaction of 3-phenylpyrazolopyrimidine (PhPP) with bromoacetone, followed by a chalcone reaction with differen...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Bhupender S. Chhikara, Sajda Ashraf, Saghar Mozaffari, Nicole St. Jeans, Dindyal Mandal, Rakesh Kumar Tiwari, Zaheer Ul-Haq, Keykavous Parang
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Subjects:	protein kinase phenylpyrazolopyrimidine antiproliferative activity enzyme inhibition molecular simulation
Online Access:	https://www.mdpi.com/1420-3049/25/9/2135