NAT10-mediated ac4C modification promotes stemness and chemoresistance of colon cancer by stabilizing NANOGP8

Background: Colon cancer (CC) stem cells can self-renew as well as expand, thereby promoting tumor progression and conferring resistance to chemotherapeutic agents. The acetyltransferase NAT10 mediates N4-acetylcytidine (ac4C) modification, which in turn drives tumorigenesis, metastasis, stemness pr...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Li-ping Gao, Ting-dong Li, Su-zhen Yang, Hui-min Ma, Xiang Wang, De-kui Zhang
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Subjects:	Colon cancer Cancer stem cell NAT10 ac4C NANOGP8
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024063618