Hydrogen Peroxide Is Responsible for the Cytotoxic Effects of Streptococcus pneumoniae on Primary Microglia in the Absence of Pneumolysin

Introduction: Streptococcus pneumoniae is the most common cause of bacterial meningitis and meningoencephalitis in humans. The bacterium produces numerous virulence determinants; among them, hydrogen peroxide (H2O2) and pneumolysin (Ply) contribute to bacterial cytotoxicity. Microglia, the resident...

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Bibliographic Details

Published in:	Journal of Innate Immunity
Main Authors:	Franziska Jennert, Désirée Schaaf, Roland Nau, Thomas P. Kohler, Sven Hammerschmidt, Darius Häusler, Peter Valentin-Weigand, Jana Seele
Format:	Article
Language:	English
Published:	Karger Publishers 2024-04-01
Subjects:	streptococcus pneumoniae hydrogen peroxide pneumolysin cell death
Online Access:	https://beta.karger.com/Article/FullText/536514