The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia

Chronic kidney disease (CKD) is characterized by the progressive loss of renal function; moreover, CKD progression commonly leads to multiple comorbidities, including neurological dysfunction and immune disorders. CKD-triggered neuroinflammation significantly contributes to cognitive impairment. Thi...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Lung-Chih Li, Wei-Yu Chen, Jin-Bor Chen, Wen-Chin Lee, Chiung-Chih Chang, Hong-Tai Tzeng, Chiang-Chi Huang, Ya-Jen Chang, Jenq-Lin Yang
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Subjects:	chronic kidney disease cognitive impairment indoxyl sulfate inflammation NLRP3 astrocyte
Online Access:	https://www.mdpi.com/2227-9059/9/9/1252