Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

We demonstrate how RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and thereby determine nematode sex. FOX-1, an RNA recognition motif protein, triggers hermaphrodite development in XX embryos by causing non-productive alternative pre-mRNA...

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Bibliographic Details

Published in:	eLife
Main Authors:	Behnom Farboud, Catherine S Novak, Monique Nicoll, Alyssa Quiogue, Barbara J Meyer
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-12-01
Subjects:	alternative pre-mRNA splicing FOX-1 RNA binding protein sex determination signal X-chromosome dose dosage compensation X-signal element
Online Access:	https://elifesciences.org/articles/62963