Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response

The unfolded protein response (UPR) is activated to cope with an accumulation of improperly folded proteins in the Endoplasmic reticulum (ER). The Inositol requiring enzyme 1α (IRE1α) is the most evolutionary conserved transducer of the UPR. Activated IRE1 forms ‘back-to-back’-dimers that enables th...

Full description

Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Kosala N. Amarasinghe, Diana Pelizzari-Raymundo, Antonio Carlesso, Eric Chevet, Leif A. Eriksson, Sayyed Jalil Mahdizadeh
Format:	Article
Language:	English
Published:	Elsevier 2022-01-01
Subjects:	IRE1α UPR Peptide docking Dimer disruptor FDA approved drugs MD simulations
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037022001040