Nucleolar and Ribosomal Dysfunction—A Common Pathomechanism in Childhood Progerias?

The nucleolus organizes around the sites of transcription by RNA polymerase I (RNA Pol I). rDNA transcription by this enzyme is the key step of ribosome biogenesis and most of the assembly and maturation processes of the ribosome occur co-transcriptionally. Therefore, disturbances in rRNA transcript...

詳細記述

書誌詳細

出版年:	Cells
主要な著者:	Tamara Phan, Fatima Khalid, Sebastian Iben
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2019-06-01
主題:	nucleolus aging Hutchinson–Gilford Progeria syndrome Cockayne syndrome trichothiodystrophy RNA polymerase I ribosome translational fidelity
オンライン･アクセス:	https://www.mdpi.com/2073-4409/8/6/534